RESUMO
The blending of natural polysaccharides with synthetic polymers has attracted much attention in drug delivery models owing to their remarkable biodegradable and biocompatible characteristics. This study focuses on the facile preparation of a sequence of composite films having Starch/Poly(allylamine hydrochloride) (ST/PAH) in different compositions to propose a novel drug delivery system (DDS). ST/PAH blend films were developed and characterized. FT-IR evaluation confirmed the involvement of intermolecular H-bonding between the ST and PAH counterparts in blended films. The water contact angle (WCA) ranged from 71° to 100° indicating that all the films were hydrophobic. TPH-1 (90 % ST and 10 % PAH) was evaluated for in vitro controlled drug release (CDR) at 37 ± 0.5 °C in a time-dependent fashion. CDR was recorded in phosphate buffer saline (PBS) and simulated gastric fluid (SGF). In the case of SGF (pH 1.2), the percentile drug release (DR) for TPH-1 was approximately 91 % in 110 min, while the maximum DR was 95 % in 80 min in PBS (pH 7.4) solution. Our results demonstrate that the fabricated biocompatible blend films can be a promising candidate for a sustained-release DDS for oral drug administration, tissue engineering, wound dressings, and other biomedical applications.
Assuntos
Sistemas de Liberação de Medicamentos , Amido , Amido/química , Liberação Controlada de Fármacos , Espectroscopia de Infravermelho com Transformada de Fourier , Sistemas de Liberação de Medicamentos/métodos , Preparações de Ação RetardadaRESUMO
In this study, a facile drug release system was developed through a solution casting technique using a combination of sodium alginate (SA), poly(ethylene glycol)monomethyl ether (mPEG) and ciprofloxacin hydrochloride (CPX). The structure of the membranes was characterized using ATR-FTIR, AFM and the static contact angle (SCA) was determined to find surface nature of membranes. ATR-FTIR confirmed the existence of intermolecular hydrogen bonding between SA/mPEG in bio-polymeric membranes. AFM micrographs exhibited the extent of roughness which decreased as the contents of mPEG in the membranes were increased up to 40% (w/w). The SCA values ranged between 24° to 84° (at 0 s) and 14° to 80° (at 60 s) and showed an increase in hydrophilicity due to the incorporation of mPEG. In vitro drug release profile of CPX loaded on a membrane comprising of SA/mPEG (80/20) was evaluated in SGF (pH 1.2) and PBS (pH 7.4) solutions till 3 h. At pH 1.2, the maximum amount of CPX (~80%) was released in 70-120 min while ~75% drug was released in 90-120 min at pH 7.4. The present study demonstrated a facile and cost-effective approach to prepare SA/mPEG membranes that may be potentially employed as a drug delivery system in various biomedical applications.
Assuntos
Materiais Biocompatíveis/química , Ciprofloxacina/química , Portadores de Fármacos/química , Polietilenoglicóis/química , Alginatos/química , Materiais Biocompatíveis/farmacologia , Ciprofloxacina/farmacologia , Preparações de Ação Retardada , Portadores de Fármacos/farmacologia , Liberação Controlada de Fármacos/efeitos dos fármacos , Humanos , Polietilenoglicóis/farmacologia , Polímeros/química , Espectroscopia de Infravermelho com Transformada de FourierRESUMO
The amalgamation of natural polysaccharides with synthetic polymers often produces fruitful results in the area of drug delivery due to their biodegradable and biocompatible nature. In this study, a series of blend films composed of chitosan (CS)/poly(allylamine hydrochloride) (PAH) in different compositions were prepared as smart drug delivery matrices. The properties of these polymeric films were then explored. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) analysis confirmed an intermolecular hydrogen bonding between CS and PAH. Atomic force microscopy (AFM) revealed improvements in surface morphology as the percentage of PAH in the blend films increased up to 60% (w/w). Water contact angle (WCA) ranged between 97° to 115°, exhibiting the hydrophobic nature of the films. Two films were selected, CTH-1 (90% CS and 10% PAH) and CTH-2 (80% CS and 20% PAH), to test for in vitro cumulative drug release (%) at 37 ± 0.5 °C as a function of time. It was revealed that for simulated gastric fluid (SGF) with pH 1.2, the cumulative drug release (CDR) for CTH-1 and CTH-2 was around 88% and 85% in 50 min, respectively. Both films converted into gel-like material after 30 min. On the other hand, in pH 7.4 phosphate buffer saline (PBS) solution, the maximum CDR for CTH-1 and CTH-2 was 93% in 90 min and 98% in 120 min, respectively. After 120 min, these films became fragments. Sustained drug release was observed in PBS, as compared to SGF, because of the poor stability of the films in the latter. These results demonstrate the excellent potential of blend films in sustained-release drug delivery systems for hydrophilic or unstable drugs.
